Activation of microsomal glutathione transferase activity by reactive intermediates formed during the metabolism of phenol.

Abstract

The activity of microsomal glutathione transferase was increased 1.7-fold in rat liver microsomes which carried out NADPH dependent metabolism of phenol. Known phenol metabolites were therefore tested for their ability to activate the microsomal glutathione transferase. The phenol metabolites benzoquinone and 1,2,4-benzenetriol both activated the… (More)

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Cite this paper

@article{Wallin1990ActivationOM, title={Activation of microsomal glutathione transferase activity by reactive intermediates formed during the metabolism of phenol.}, author={H{\aa}kan Wallin and Rachelle Morgenstern}, journal={Chemico-biological interactions}, year={1990}, volume={75 2}, pages={185-99} }