Activation of microglial cells by β-amyloid protein and interferon-γ

ALZHEIMER'S disease is the most common cause of progressive intellectual failure1. The lesions that develop, called senile plaques, are extracellular deposits principally composed of insoluble aggregates of β-amyloid protein (Aβ), infiltrated by reactive microglia and astrocytes2,3. Although Aβ, and a portion of it, the fragment 25–35 (Aβ(25–35)), have been… (More)