Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases.

@article{Harrigan2008ActivationOM,
  title={Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases.},
  author={Timothy J. Harrigan and Iskandar F. Abdullaev and David Jourd'heuil and Alexander A Mongin},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 6},
  pages={2449-62}
}
Microglia are the resident immune cells of the CNS, which are important for preserving neural tissue functions, but may also contribute to neurodegeneration. Activation of these cells in infection, inflammation, or trauma leads to the release of various toxic molecules, including reactive oxygen species (ROS) and the excitatory amino acid glutamate. In this study, we used an electrophysiologic approach and a D-[(3)H]aspartate (glutamate) release assay to explore the ROS-dependent regulation of… CONTINUE READING

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