Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury.

@article{Terayama2008ActivationOM,
  title={Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury.},
  author={Ryuji Terayama and Shinji Omura and Naoko Fujisawa and Tomoichiro Yamaai and Hiroyuki Ichikawa and Tomosada Sugimoto},
  journal={Neuroscience},
  year={2008},
  volume={153 4},
  pages={1245-55}
}
The activation of glial cells in the CNS has been suggested to be involved in abnormal pain sensation after peripheral nerve injury. Previous studies demonstrated phosphorylation of p38 mitogen-activated protein kinase (MAPK) in spinal cord glial cells after peripheral nerve injury, and such phosphorylation has been suggested to be involved in the development of neuropathic pain. The aim of this study was to examine the dorsal column nuclei for phosphorylation of p38 MAPK following peripheral… CONTINUE READING