Activation of mianserin and its metabolites by human liver microsomes.

  title={Activation of mianserin and its metabolites by human liver microsomes.},
  author={Camille Lambert and Brian Kevin Park and Neil R. Kitteringham},
  journal={Biochemical pharmacology},
  volume={38 17},
Human liver microsomes metabolise mianserin to the stable 8-hydroxymianserin, desmethylmianserin and mianserin-2-oxide and in addition to one or more chemically reactive metabolites which bind, irreversibly, to microsomal protein. The stable metabolites were isolated by HPLC and characterized by mass spectrometry. The generation of each of these metabolites showed substantial inter-individual variation between eight sets of human liver microsomes studied. Inhibition of irreversible binding was… CONTINUE READING