Activation of miR-31 function in already-established metastases elicits metastatic regression.

@article{Valastyan2011ActivationOM,
  title={Activation of miR-31 function in already-established metastases elicits metastatic regression.},
  author={Scott Valastyan and Amelia Chang and Nathan Benaich and Ferenc Reinhardt and Robert A Weinberg},
  journal={Genes & development},
  year={2011},
  volume={25 6},
  pages={646-59}
}
Distant metastases, rather than the primary tumors from which these lesions arise, are responsible for >90% of carcinoma-associated mortality. Many patients already harbor disseminated tumor cells in their bloodstream, bone marrow, and distant organs when they initially present with cancer. Hence, truly effective anti-metastatic therapeutics must impair the… CONTINUE READING