Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal

@article{Waly2004ActivationOM,
  title={Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal},
  author={Mostafa Waly and Horatiu Olteanu and Ranjita Banerjee and S-w Choi and Jeffrey B Mason and Belinda S Parker and Saraswati V. Sukumar and Sangwoo Shim and A Sharma and Jorge Benzecry and V-A Power-Charnitsky and Richard C. Deth},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={358-370}
}
Methylation events play a critical role in the ability of growth factors to promote normal development. Neurodevelopmental toxins, such as ethanol and heavy metals, interrupt growth factor signaling, raising the possibility that they might exert adverse effects on methylation. We found that insulin-like growth factor-1 (IGF-1)- and dopamine-stimulated methionine synthase (MS) activity and folate-dependent methylation of phospholipids in SH-SY5Y human neuroblastoma cells, via a PI3-kinase- and… CONTINUE READING

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