Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

@article{Bruno1995ActivationOM,
  title={Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells},
  author={Valeria Bruno and Agata Copani and Thomas Kn{\"o}pfel and Rainer Kuhn and Giacomo Casabona and P. Dell' Albani and Daniele Filippo Condorelli and Ferdinando Nicoletti},
  journal={Neuropharmacology},
  year={1995},
  volume={34},
  pages={1089-1098}
}
We have studied the influence of class I metabotropic glutamate receptors (mGluRs) on excitotoxic neuronal degeneration in cultured murine cortical neurons grown on a monolayer of astrocytes. These cultures expressed high levels of mGluR5 mRNA, which were comparable to those found in RNA extracts from cerebral cortex. Cortical neurons in mixed cultures were heavily stained with antibodies raised against mGluR5 and were also stained--albeit to a much lower extent--with mGluR1a but not with… Expand
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It is suggested that stimulation of cyclic-AMP-linked metabotropic glutamate receptors inhibits ionotropic glutamate receptor-mediated activation of apoptotic cascades involving IkappaB-alpha degradation and nuclear factor-kappaB nuclear translocation, as well as p53 and c-Myc induction. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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References

SHOWING 1-10 OF 49 REFERENCES
Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.
  • J. Koh, E. Palmer, C. Cotman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
Concomitant activation of the ACPD receptor may serve as a protective mechanism against neurotoxicity that could be produced by brief intense NMDA receptor activation during normal or abnormal brain function. Expand
Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.
TLDR
The neuroprotective activity of mGluR agonists may be related to their ability to inhibit membrane Ca2+ conductance, because drugs that block voltage-sensitive Ca1+ channels, such as nimodipine or Co2+, could also attenuate beta AP(25-35)-induced apoptosis. Expand
Trans-azetidine-2,4-dicarboxylic acid activates neuronal metabotropic receptors.
TLDR
The new rigid glutamate analogue, (+/-)-trans-azetidine-2,4-dicarboxylic acid (t-ADA) might prove useful in differentiating the function of various mGluR subtypes, suggesting that t-ADA acts on a subtype of metabotropic receptors different from mGLUR1. Expand
Metabotropic glutamate receptors and neuronal toxicity.
TLDR
A role for metabotropic receptors in the mechanism of neuronal degeneration has been suggested and the problem of toxic effects of quisqualate in hippocampal slices and cultured cortical neurons is addressed. Expand
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
TLDR
(1S,3R)-ACPD markedly potentiated increases in the intracellular Ca2+ concentration induced by NMDA, AMPA, and KA but not by 10-50 mM KCl, and may play an important role in the regulation of ionotropic responses mediated by glutamate in the spinal cord. Expand
Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.
TLDR
The glutamate-evoked PKC translocation is Mg2+ sensitive, is prevented by 2-amino-5-phosphonovalerate and phencyclidine, is not inhibited by nitrendipine but is abolished by the removal of Ca2+ from the incubation medium, suggesting that glutamate-mediated Ca2-mediated influx is operative in the redistribution of PKC. Expand
3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus
TLDR
In the rat hippocampus, 3,5‐dihydroxyphenylglycine can be used to activate subpopulations of mGluRs coupled to phosphoinositide hydrolysis with minimal effects on cAMP‐mGluR second messenger systems. Expand
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
TLDR
The presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals is demonstrated and may have a physiological role in the maintenance of long-term potentiation. Expand
Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4
The metabotropic glutamate receptors are coupled to intracellular signal transduction via G-proteins and consist of a family of at least five different subtypes, termed mGluR1-mGluR5. We studied theExpand
Protein kinase C‐mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.
TLDR
A role for metabotropic glutamate receptors in modulation of NMDA‐mediated processes is suggested in Xenopus oocytes injected with rat brain RNA and under conditions that eliminate the oocyte's endogenous calcium‐dependent chloride current. Expand
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