Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine.

@article{Winder1993ActivationOM,
  title={Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine.},
  author={Danny G. Winder and P Jeffrey Conn},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1993},
  volume={13 1},
  pages={38-44}
}
Metabotropic glutamate receptors (mGluRs) are coupled to effector systems through GTP-binding proteins (G-proteins) and appear to mediate slow synaptic responses in the CNS. Although mGluR-mediated increases in phosphoinositide hydrolysis have been well characterized, other mechanisms for signal transduction employed by mGluRs are poorly understood. We recently reported that the selective mGluR agonist 1-aminocyclopentane-1 S,3R-dicarboxylic acid (1S,3R-ACPD) increases cAMP accumulation in rat… CONTINUE READING
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Pharmacology and physiology of metabotropic glutamate receptors in mammalian central nervous system

  • NW DeLapp, K Eckols
  • Drug Dev Res
  • 1992
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