Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.

@article{Mukhin1996ActivationOM,
  title={Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.},
  author={Alexey G. Mukhin and Lei Fan and Alan I. Faden},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 19},
  pages={
          6012-20
        }
}
The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1 and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro models. Traumatic injury to mixed neuronal/glial cultures induced phosphoinositide hydrolysis and caused neuronal death. Pharmacological blockade of group I receptors significantly reduced these effects in vitro and decreased neurological deficits as well as neuronal loss produced by traumatic brain injury in vivo. In… CONTINUE READING

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