Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats.

@article{Wang2013ActivationOM,
  title={Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats.},
  author={Jia-wei Wang and Han-dong Wang and Zixiang Cong and Xiang-Sheng Zhang and Xiao-ming Zhou and Dingding Zhang},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={430 3},
  pages={
          1016-21
        }
}
A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI). In vitro studies were reported that activation of metabotropic glutamate receptor 5 (mGluR5) could inhibit the microglia-associated inflammation in response to lipopolysaccharide and our previous study indicated that mGluR5 was expressed in activated microglia following TBI. However, there is little known about… Expand
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