Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies.

@article{Hutson2000ActivationOM,
  title={Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies.},
  author={Peter H. Hutson and Cheryl L. Barton and Michael J Jay and Peter Blurton and Frank Burkamp and Robert B. Clarkson and Linda J. Bristow},
  journal={Neuropharmacology},
  year={2000},
  volume={39 12},
  pages={2318-28}
}
Administration of the non-competitive NMDA receptor antagonists phencyclidine (PCP) (0.6-5 mg/kg s.c.) and MK-801 (0.1-0.8 mg/kg s.c. ) dose-dependently increased locomotor activity in the rat. Pre-treatment of rats with SB 221284 (0.1-1 mg/kg, i.p.) a 5-HT(2C/2B) receptor antagonist or SB 242084 (1 mg/kg, i.p.) a selective 5-HT(2C) receptor antagonist… CONTINUE READING