Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL.


Acidic conditions, such as those inside phagosomes, stimulate the intracellular pathogen Salmonella enterica to activate virulence genes. The sensor PhoQ responds to a mildly acidic pH by phosphorylating, and thereby activating, the virulence regulator PhoP. This PhoP/PhoQ two-component system is conserved in a subset of Gram-negative bacteria. PhoQ is… (More)
DOI: 10.1126/scisignal.aan6284


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