Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.

@article{Gulla2010ActivationOM,
  title={Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.},
  author={Krishana Chaitanya Gulla and Kshitij Gupta and Anders Krarup and Peter N. Gal and Wilhelm J Schwaeble and Robert B Sim and C. David O'Connor and Krishnan Hajela},
  journal={Immunology},
  year={2010},
  volume={129 4},
  pages={482-95}
}
The lectin pathway of complement is activated upon binding of mannan-binding lectin (MBL) or ficolins (FCNs) to their targets. Upon recognition of targets, the MBL-and FCN-associated serine proteases (MASPs) are activated, allowing them to generate the C3 convertase C4b2a. Recent findings indicate that the MASPs also activate components of the coagulation system. We have previously shown that MASP-1 has thrombin-like activity whereby it cleaves and activates fibrinogen and factor XIII. MASP-2… CONTINUE READING

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