Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia.

@article{Ljungberg2006ActivationOM,
  title={Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia.},
  author={M. Cecilia Ljungberg and Meenakshi B. Bhattacharjee and Yaojuan Lu and Dawna La-Vina Duncan Armstrong and Daniel Yoshor and John W. Swann and Michael J. Sheldon and G V D'arcangelo},
  journal={Annals of neurology},
  year={2006},
  volume={60 4},
  pages={420-9}
}
OBJECTIVE The cortex of patients with cortical dysplasia contains several abnormal cell types. Among the dysplastic cells, cytomegalic neurons are known to be electrically hyperactive and may contribute to epileptic activity. In this study, we sought to identify molecular markers of cytomegalic neurons in focal or hemispheric cortical dysplasia and to determine whether the activity of the mammalian target of rapamycin (mTOR) kinase is abnormally high in these cells. METHODS Microarray… CONTINUE READING

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