Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas

@inproceedings{Maniscalco2013ActivationOM,
  title={Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas},
  author={Lorella Maniscalco and Yolanda Mill{\'a}n and Selina Iussich and Mauro Denina and R S{\'a}nchez-C{\'e}spedes and Francesca Gattino and Bartolomeo Biolatti and Nobuo Sasaki and Takayuki Nakagawa and Maria Flavia Di Renzo and Juana Mart{\'i}n de las Mulas and Raffaella De Maria},
  booktitle={BMC veterinary research},
  year={2013}
}
BACKGROUND Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in TNBC and it represents a potential target for the treatment of this aggressive tumour. Feline mammary carcinoma (FMC) is considered to be a model for hormone-independent human breast cancer. This study investigated mTOR and p-mTOR expression in FMC in relation to triple… CONTINUE READING
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