Activation of macrophages by linear (1right-arrow3)-beta-D-glucans. Impliations for the recognition of fungi by innate immunity.

@article{Kataoka2002ActivationOM,
  title={Activation of macrophages by linear (1right-arrow3)-beta-D-glucans. Impliations for the recognition of fungi by innate immunity.},
  author={Keiko Kataoka and Tatsushi Muta and Soh Yamazaki and Koichiro Takeshige},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={36825-31}
}
Although (1-->3)-beta-d-glucans, which are one of major fungal cell wall components, are known to activate invertebrate innate immune systems, their activities on mammalian cells remain elusive. Here, we report their activities on mouse macrophages. Among the various (1-->3)-beta-d-glucans, curdlan, a linear (1-->3)-beta-d-glucan, although not branched beta-glucans, exhibits significant activity to stimulate nuclear factor-kappaB in macrophages. The activity of curdlan is dramatically enhanced… CONTINUE READING
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