Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise.

@article{Moberg2016ActivationOM,
  title={Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise.},
  author={Marcus Moberg and William Apr{\'o} and Bj{\"o}rn Arpi Ekblom and Gerrit van Hall and Hans-Christer Holmberg and Eva Blomstrand},
  journal={American journal of physiology. Cell physiology},
  year={2016},
  volume={310 11},
  pages={
          C874-84
        }
}
Protein synthesis is stimulated by resistance exercise and intake of amino acids, in particular leucine. Moreover, activation of mammalian target of rapamycin complex 1 (mTORC1) signaling by leucine is potentiated by the presence of other essential amino acids (EAA). However, the contribution of the branched-chain amino acids (BCAA) to this effect is yet unknown. Here we compare the stimulatory role of leucine, BCAA, and EAA ingestion on anabolic signaling following exercise. Accordingly, eight… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 53 references

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 7 Excerpts
Highly Influenced

Quantitative amino acid profiling and stable isotopically labeled amino acid tracer enrichment used for in vivo human systemic and tissue kinetics measurements.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences • 2014
View 4 Excerpts
Highly Influenced

Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme • 2014
View 1 Excerpt

Determination of human muscle protein fractional synthesis rate: an evaluation of different mass spectrometry techniques and considerations for tracer choice

A Borno, CJ Hulston, G. van Hall
J Mass Spectrom • 2014
View 1 Excerpt