Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target.

@article{Huang2013ActivationOM,
  title={Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target.},
  author={Yulun Huang and Matthias A Karajannis and David Zagzag and Smit S. Shah and Iren Horkayne-Szakaly and Elisabeth Jane Rushing and James D. Cameron and Deepali Jain and Charles G. Eberhart and Eric H Raabe and Fausto J Rodriguez},
  journal={Neuro-oncology},
  year={2013},
  volume={15 12},
  pages={
          1604-14
        }
}
BACKGROUND Previous studies support a role for mitogen-activated protein kinase pathway signaling, and more recently Akt/mammalian target of rapamycin (mTOR), in pediatric low-grade glioma (PLGG), including pilocytic astrocytoma (PA). Here we further evaluate the role of the mTORC1/mTORC2 pathway in order to better direct pharmacologic blockade in these common childhood tumors. METHODS We studied 177 PLGGs and PAs using immunohistochemistry and tested the effect of mTOR blockade on 2 PLGG… CONTINUE READING

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