Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.

@article{Tachibana2012ActivationOL,
  title={Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.},
  author={Hiromi Tachibana and Daisuke Ogawa and Yuichi Matsushita and Dennis Bruemmer and Jun Wada and Sanae Teshigawara and Jun Eguchi and Chikage Sato-Horiguchi and Haruhito A Uchida and Kenichi Shikata and Hirofumi Makino},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2012},
  volume={23 11},
  pages={1835-46}
}
Osteopontin is a proinflammatory cytokine and monocyte chemoattractant implicated in the pathogenesis of diabetic nephropathy. Synthetic agonists for liver X receptors (LXRs) suppress the expression of proinflammatory genes, including osteopontin, but whether LXR activation modulates diabetic nephropathy is unknown. We administered the LXR agonist T0901317 to mice with streptozotocin-induced diabetes and evaluated its effects on diabetic nephropathy. The LXR agonist decreased urinary albumin… CONTINUE READING