Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.

@article{Laffitte2003ActivationOL,
  title={Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.},
  author={Bryan A. Laffitte and Lily C Chao and Jing Li and Robert Walczak and Sarah Hummasti and Sean B. Joseph and Antonio Castrillo and Damien C Wilpitz and David J Mangelsdorf and Jon L. Collins and Enrique Saez and Peter Tontonoz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 9},
  pages={5419-24}
}
The control of lipid and glucose metabolism is closely linked. The nuclear receptors liver X receptor (LXR)alpha and LXR beta have been implicated in gene expression linked to lipid homeostasis; however, their role in glucose metabolism is not clear. We demonstrate here that the synthetic LXR agonist GW3965 improves glucose tolerance in a murine model of diet-induced obesity and insulin resistance. Analysis of gene expression in LXR agonist-treated mice reveals coordinate regulation of genes… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
186 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 186 extracted citations

Similar Papers

Loading similar papers…