Activation of leukocytes during the uteroplacental passage in preeclampsia.

  title={Activation of leukocytes during the uteroplacental passage in preeclampsia.},
  author={Jan Roar Mellembakken and P{\aa}l Aukrust and Mette Kl\ovstad Olafsen and Thor Ueland and Kjetil Hestdal and Vibeke Videm},
  volume={39 1},
Endothelial dysfunction and inflammation appear to play a major role in the pathogenesis of preeclampsia. We hypothesize that a chronic inflammation in the decidua and placenta during preeclampsia may lead to a local leukocyte activation in this compartment. Venous blood was sampled simultaneously from antecubital and uterine veins during cesarean sections in 30 women with preeclampsia, 29 with uncomplicated pregnancies, and from 17 nonpregnant women. The expression of adhesion molecules and… CONTINUE READING