Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3, a snake venom hemorrhagic metalloproteinase.

@article{Menezes2008ActivationOL,
  title={Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3, a snake venom hemorrhagic metalloproteinase.},
  author={Milene Cristina Menezes and Adriana Franco Paes Leme and Robson Melo and Carlos Antonio Leite Silva and Maisa Splendore Della Casa and Fernanda Miriani Bruni and Carla Andrade Lima and Monica Lopes-Ferreira and Ant{\^o}nio Carlos M. Camargo and Jay William Fox and Solange M. T. Serrano},
  journal={FEBS letters},
  year={2008},
  volume={582 28},
  pages={
          3915-21
        }
}
The functionality of the disintegrin-like/cysteine-rich domains of snake venom metalloproteinases (SVMPs) has been shown to reside in the cysteine-rich region, which can interact with VWA-containing proteins. Recently, the hyper-variable region (HVR) of the cysteine-rich domain was suggested to constitute a potential protein-protein adhesive interface. Here we show that recombinant proteins of HF3, a hemorrhagic P-III SVMP, containing the cysteine-rich domain (disintegrin-like/cysteine-rich and… CONTINUE READING
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