Activation of latent transforming growth factor-&bgr;1, a conserved function for pregnancy-specific beta 1-glycoproteins

  title={Activation of latent transforming growth factor-&bgr;1, a conserved function for pregnancy-specific beta 1-glycoproteins},
  author={J. Warren and Michelle Im and A. Ballesteros and C. Ha and T. Moore and F. Lambert and S. Lucas and B. Hinz and G. Dveksler},
  journal={MHR: Basic science of reproductive medicine},
  • J. Warren, Michelle Im, +6 authors G. Dveksler
  • Published 2018
  • Biology, Medicine
  • MHR: Basic science of reproductive medicine
  • STUDY QUESTION Do all 10 human pregnancy-specific beta 1-glycoproteins (PSGs) and murine PSG23 activate latent transforming growth factor-β1 (TGF-β1)? SUMMARY ANSWER All human PSGs and murine PSG23 activated latent TGF-β1. WHAT IS KNOWN ALREADY Two of the 10 members of the PSG1 family, PSG1 and PSG9, were previously shown to activate the soluble small latent complex of TGF-β1, a cytokine with potent immune suppressive functions. STUDY DESIGN, SIZE, DURATION Recombinant PSGs were generated… CONTINUE READING
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