Activation of latent precursors in the hippocampus is dependent on long-term potentiation

@inproceedings{Kameda2012ActivationOL,
  title={Activation of latent precursors in the hippocampus is dependent on long-term potentiation},
  author={Masahiro Kameda and Catherine Taylor and Tara Walker and Debra M. Black and Wickliffe C. Abraham and Perry F. Bartlett},
  booktitle={Translational Psychiatry},
  year={2012}
}
The recent discovery of a large latent population of precursor cells in the dentate gyrus of adult mice led us to investigate whether activation of this population is regulated by synaptic activity, thereby explaining the observation that environmental signals can affect neurogenesis. Using a variety of stimulation protocols, we found that only a long-term potentiation (LTP)-inducing protocol activated the latent precursor pool, leading to increased neurogenesis in the dentate gyrus. LTP… CONTINUE READING
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