Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator

@article{Chen2001ActivationOL,
  title={Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator},
  author={J. Chen and K. Ueda and S. Sakakibara and T. Okuno and C. Parravicini and M. Corbellino and K. Yamanishi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98},
  pages={4119 - 4124}
}
  • J. Chen, K. Ueda, +4 authors K. Yamanishi
  • Published 2001
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • Kaposi's sarcoma-associated herpesvirus (KSHV) is strongly linked to Kaposi's sarcoma, primary effusion lymphomas, and a subset of multicentric Castleman's disease. The mechanism by which this virus establishes latency and reactivation is unknown. KSHV Lyta (lytic transactivator, also named KSHV/Rta), mainly encoded by the ORF 50 gene, is a lytic switch gene for viral reactivation from latency, inasmuch as it is both essential and sufficient to drive the entire viral lytic cycle. Here we show… CONTINUE READING
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