Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator.

@article{Chen2001ActivationOL,
  title={Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator.},
  author={Jingjing Chen and Kunihiro Ueda and Shuhei Sakakibara and Toshiomi Okuno and Carlo Parravicini and Mario Corbellino and Kouichi Yamanishi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 7},
  pages={
          4119-24
        }
}
Kaposi's sarcoma-associated herpesvirus (KSHV) is strongly linked to Kaposi's sarcoma, primary effusion lymphomas, and a subset of multicentric Castleman's disease. The mechanism by which this virus establishes latency and reactivation is unknown. KSHV Lyta (lytic transactivator, also named KSHV/Rta), mainly encoded by the ORF 50 gene, is a lytic switch gene for viral reactivation from latency, inasmuch as it is both essential and sufficient to drive the entire viral lytic cycle. Here we show… CONTINUE READING

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