Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: cytokine challenge increases production of 3-hydroxykynurenine.

Abstract

Accumulating data suggest a causative link between immune stimulation, disturbed metabolism of tryptophan, and pathogenesis of bipolar disorder and schizophrenia. The goal of this study was to examine the production of kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK) and the expression of kynurenine pathway enzymes involved in their synthesis and… (More)
DOI: 10.1016/j.jpsychires.2013.08.008

Topics

4 Figures and Tables

Statistics

0204020142015201620172018
Citations per Year

54 Citations

Semantic Scholar estimates that this publication has 54 citations based on the available data.

See our FAQ for additional information.