Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells.

@article{Ehrenfeld2011ActivationOK,
  title={Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells.},
  author={Pamela Ehrenfeld and Iv{\'a}n Conejeros and Mar{\'i}a F Pavicic and Carola E. Matus and Carlos B. Gonz{\'a}lez and Andrew F. G. Quest and Kanti D. Bhoola and Mar{\'i}a Teresa Poblete and Rafael A Burgos and Carlos D. Figueroa},
  journal={Cancer letters},
  year={2011},
  volume={301 1},
  pages={106-18}
}
The kinin B(1) receptor (B(1)R) agonist Lys-des[Arg(9)]-bradykinin (LDBK) increases proliferation of estrogen-sensitive breast cancer cells by a process involving activation of the epidermal growth factor receptor (EGFR) and downstream signaling via the ERK1/2 mitogen-activated protein kinase pathway. Here, we investigated whether B(1)R stimulation induced release of the extracellular matrix metalloproteases MMP-2 and MMP-9 via ERK-dependent pathway in both estrogen-sensitive MCF-7 and… CONTINUE READING
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