Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.

@article{Wu2012ActivationOI,
  title={Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.},
  author={Lan Wu and Vrajesh V. Parekh and Curtis L. Gabriel and Deanna P. Bracy and Pamela A. Marks-Shulman and Robyn A Tamboli and Sungjune Kim and Yanice V M{\'e}ndez-Fern{\'a}ndez and Gurdyal S Besra and Jefferson P. Lomenick and Brandon Williams and David H. Wasserman and Luc Van Kaer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 19},
  pages={E1143-52}
}
Obesity triggers a low-grade systemic inflammation, which plays an important role in the development of obesity-associated metabolic diseases. In searching for links between lipid accumulation and chronic inflammation, we examined invariant natural killer T (iNKT) cells, a subset of T lymphocytes that react with lipids and regulate inflammatory responses. We show that iNKT cells respond to dietary lipid excess and become activated before or at the time of tissue recruitment of inflammatory… CONTINUE READING
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