Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses.

@article{Grajewski2008ActivationOI,
  title={Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses.},
  author={Rafael S. Grajewski and Anna M Hansen and Rajeev Kumar Agarwal and Mitchell Kronenberg and St{\'e}phan{\'e} Sidobre and Shao Bo Su and Phyllis B. Silver and Moriya Tsuji and Richard W. Franck and Anne P. Lawton and C. -K. Chan and Rachel R Caspi},
  journal={Journal of immunology},
  year={2008},
  volume={181 7},
  pages={4791-7}
}
Invariant NKT cells (iNKT cells) have been reported to play a role not only in innate immunity but also to regulate several models of autoimmunity. Furthermore, iNKT cells are necessary for the generation of the prototypic eye-related immune regulatory phenomenon, anterior chamber associated immune deviation (ACAID). In this study, we explore the role of… CONTINUE READING