Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

@article{Libermann1990ActivationOI,
  title={Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.},
  author={T. A. Libermann and David Baltimore},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 5},
  pages={2327-34}
}
The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids… CONTINUE READING
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