Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA.

Abstract

2'-5' oligoadenylate (2-5(A)) synthetase and protein kinase, RNA activated (PKR) are the only two known enzymes that bind double-stranded RNA (dsRNA) and get activated by it. We have previously identified their dsRNA binding domains, which do not have any sequence homology. Here, we report a profound difference between the two enzymes with respect to the… (More)

Topics

Cite this paper

@article{Desai1995ActivationOI, title={Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA.}, author={Salil Desai and Rakesh Patel and G. C. Sen and P. Malhotra and Ghanashyam D. Ghadge and Bayer Thimmapaya}, journal={The Journal of biological chemistry}, year={1995}, volume={270 7}, pages={3454-61} }