Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA.

@article{Desai1995ActivationOI,
  title={Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA.},
  author={Shailesh Y. Desai and Rekha C Patel and Ganes C Sen and Pawan Malhotra and Ghanashyam D. Ghadge and Bayar Thimmapaya},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 7},
  pages={3454-61}
}
2'-5' oligoadenylate (2-5(A)) synthetase and protein kinase, RNA activated (PKR) are the only two known enzymes that bind double-stranded RNA (dsRNA) and get activated by it. We have previously identified their dsRNA binding domains, which do not have any sequence homology. Here, we report a profound difference between the two enzymes with respect to the structural features of the dsRNA that are required for their activation. The adenoviral virus-associated type I (VAI) RNA cannot activate PKR… CONTINUE READING