Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.

@article{Tzima2001ActivationOI,
  title={Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.},
  author={Eleni Tzima and Miguel Angel Del Pozo and Sanford J Shattil and Shu Chien and Martin A Schwartz},
  journal={The EMBO journal},
  year={2001},
  volume={20 17},
  pages={4639-47}
}
Fluid shear stress is a critical determinant of vascular remodeling and atherogenesis. Both integrins and the small GTPase Rho are implicated in endothelial cell responses to shear but the mechanisms are poorly understood. We now show that shear stress rapidly stimulates conformational activation of integrin alpha(v)beta3 in bovine aortic endothelial cells, followed by an increase in its binding to extracellular cell matrix (ECM) proteins. The shear-induced new integrin binding to ECM induces a… CONTINUE READING
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