Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.

@article{Lehnardt2003ActivationOI,
  title={Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.},
  author={Seija Lehnardt and Leon J Massillon and Pamela L. Follett and Frances E. Jensen and Rajiv R Ratan and Paul B Rosenberg and Joseph J. Volpe and Timothy Vartanian},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 14},
  pages={8514-9}
}
Innate immunity is an evolutionarily ancient system that provides organisms with immediately available defense mechanisms through recognition of pathogen-associated molecular patterns. We show that in the CNS, specific activation of innate immunity through a Toll-like receptor 4 (TLR4)-dependent pathway leads to neurodegeneration. We identify microglia as the major lipopolysaccharide (LPS)-responsive cell in the CNS. TLR4 activation leads to extensive neuronal death in vitro that depends on the… CONTINUE READING
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