Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like disease.

@article{Nandula2011ActivationOI,
  title={Activation of innate immunity accelerates sialoadenitis in a mouse model for Sj{\"o}gren's syndrome-like disease.},
  author={S R Nandula and Yogesh M Scindia and Paromita Dey and Harini Bagavant and Umesh S. Deshmukh},
  journal={Oral diseases},
  year={2011},
  volume={17 8},
  pages={801-7}
}
OBJECTIVE Sjögren's syndrome is a chronic autoimmune disorder characterized by progressive lymphocytic infiltration within the salivary and lacrimal glands. This study was undertaken to investigate the effects of innate immunity activation on sialoadenitis in a mouse strain genetically susceptible for development of SS-like disease. METHODS Female New Zealand Black X New Zealand White F1 mice were repeatedly treated with toll-like 3 receptor agonist poly(I:C). Submandibular glands were… CONTINUE READING