Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells.

@article{Hirata2007ActivationOI,
  title={Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells.},
  author={Yoshihiro Hirata and Alexis H. Broquet and Luis Alberto Mench{\'e}n and Martin F. Kagnoff},
  journal={Journal of immunology},
  year={2007},
  volume={179 8},
  pages={5425-32}
}
Intestinal epithelial cells (IECs) are a first line of defense against microbial pathogens that enter the host through the intestinal tract. Moreover, viral pathogens that infect the host via the intestinal epithelium are an important cause of morbidity and mortality. However, the mechanisms by which viral pathogens activate antiviral defense mechanisms in IECs are largely unknown. The synthetic dsRNA analog polyinosinic-polycytidylic acid and infection with live virus were used to probe the… CONTINUE READING
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