Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.

@article{BttcherFriebertshuser2013ActivationOI,
  title={Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.},
  author={Eva B{\"o}ttcher-Friebertsh{\"a}user and H -D Klenk and Wolfgang Garten},
  journal={Pathogens and disease},
  year={2013},
  volume={69 2},
  pages={87-100}
}
Influenza is an acute infection of the respiratory tract, which affects each year millions of people. Influenza virus infection is initiated by the surface glycoprotein hemagglutinin (HA) through receptor binding and fusion of viral and endosomal membranes. HA is synthesized as a precursor protein and requires cleavage by host cell proteases to gain its fusion capacity. Although cleavage of HA is crucial for virus infectivity, little was known about relevant proteases in the human airways for a… CONTINUE READING
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Isolation and characterization of a novel trypsinlike protease found in rat bronchiolar epithelial Clara cells . A possible activator of the viral fusion glycoprotein

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