Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA.

@article{Lee2003ActivationOI,
  title={Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA.},
  author={M T Michael Lee and Klaus Klumpp and Paul Digard and Laurence S. Tiley},
  journal={Nucleic acids research},
  year={2003},
  volume={31 6},
  pages={1624-32}
}
The current model for influenza virus mRNA transcription involves the sequential interaction of the viral polymerase with the 5'- and 3'-ends of vRNA, with each RNA-protein interaction triggering a polymerase function necessary for cap-primed transcription. Here we show that the order in which this ternary complex is assembled is in fact important. Polymerase bound simultaneously to a pre-annealed duplex of the 5'- and 3'-ends of vRNA had greatly increased levels of primer binding and… CONTINUE READING
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