Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study.

@article{Niinisalo2010ActivationOI,
  title={Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study.},
  author={Petri Niinisalo and Niku Oksala and Mari Levula and Markku Pelto-Huikko and Otso J{\"a}rvinen and J. Salenius and Leena Kyt{\"o}m{\"a}ki and Juhani T. Soini and Mika K{\"a}h{\"o}nen and Reijo Laaksonen and Mikko A. Hurme and Terho Lehtim{\"a}ki},
  journal={Annals of medicine},
  year={2010},
  volume={42 1},
  pages={55-63}
}
OBJECTIVE We aimed to characterize the expression of indoleamine 2,3-dioxygenase (IDO) or IDO-induced tryptophan degradation-dependent pathways, which may lead to suppression of T cells and possible protection against atherosclerosis. METHODS AND RESULTS Expression of IDO and IDO-related pathway components was analyzed in advanced human atherosclerotic plaques (n = 24) and in non-atherosclerotic arteries (n = 6). Up-regulation of IDO and genes related to the IDO pathway was found to be… CONTINUE READING

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