Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

@article{Lander1993ActivationOH,
  title={Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.},
  author={Harry M. Lander and Prabodh K Sehajpal and Daniel M. Levine and Abraham Novogrodsky},
  journal={Journal of immunology},
  year={1993},
  volume={150 4},
  pages={1509-16}
}
Recent work in this laboratory has identified immune-stimulatory properties of the oxidant hemin. In this study, we examined whether the nitrogen-based oxidant nitric oxide (NO) had inductive effects on human lymphocytes. We found that the NO-generating compounds sodium nitroprusside and S-nitroso-N-acetylpenicillamine rapidly enhanced the rate of glucose transport in resting human PBMC. In addition, NF-kappa B binding activity was induced by these agents as was the secretion of TNF-alpha. The… CONTINUE READING