Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.

@article{Fueller2003ActivationOH,
  title={Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.},
  author={Markus Fueller and De An Wang and Gabor Tigyi and Wolfgang Siess},
  journal={Cellular signalling},
  year={2003},
  volume={15 4},
  pages={367-75}
}
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are serum-borne lipid mediators with potential proinflammatory and atherogenic properties. We studied the effects of LPA and S1P on [Ca(2+)](i), a second messenger of cellular activation, in human monocytic Mono Mac 6 (MM6) cells. LPA and S1P induced [Ca(2+)](i) transients with EC(50) values of… CONTINUE READING