Activation of human monocyte-derived dendritic cells by Burkholderia pseudomallei does not require binding to the C-type lectin DC-SIGN.

@article{Charoensap2008ActivationOH,
  title={Activation of human monocyte-derived dendritic cells by Burkholderia pseudomallei does not require binding to the C-type lectin DC-SIGN.},
  author={Jaruek Charoensap and Anneke Engering and Pongsak Utaisincharoen and Yvette van Kooyk and Stitaya Sirisinha},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={2008},
  volume={102 Suppl 1},
  pages={S76-81}
}
Dendritic cells (DCs) are essential in regulating adaptive immunity. DC-SIGN (DC-specific ICAM-grabbing nonintegrin) is a C-type lectin receptor that is expressed mainly by DCs. Accumulating evidence supports that certain pathogens target DC-SIGN to escape host immunity. To investigate a possible role of DC-SIGN in Burkholderia pseudomallei infection, we initially screened its DC-SIGN binding activity by an ELISA method utilizing a DC-SIGN-Fc chimeric protein and found that all of the B… CONTINUE READING

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