Activation of human meiosis-specific recombinase Dmc1 by Ca2+.

  title={Activation of human meiosis-specific recombinase Dmc1 by Ca2+.},
  author={Dmitry V. Bugreev and Efim I. Golub and Alicja Z. Stasiak and Andrzej Stasiak and A. V. Mazin},
  journal={The Journal of biological chemistry},
  volume={280 29},
Rad51 and its meiotic homolog Dmc1 are key proteins of homologous recombination in eukaryotes. These proteins form nucleoprotein complexes on single-stranded DNA that promote a search for homology and that perform DNA strand exchange, the two essential steps of genetic recombination. Previously, we demonstrated that Ca2+ greatly stimulates the DNA strand exchange activity of human (h) Rad51 protein (Bugreev, D. V., and Mazin, A. V. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 9988-9993). Here… CONTINUE READING

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