Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis.

@article{Cheung2010ActivationOH,
  title={Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis.},
  author={Phyllis Fung-Yi Cheung and Chun Kwok Wong and Amy Wing-Yin Ho and Shuiqing Hu and Dapeng Chen and C. K. Lam},
  journal={International immunology},
  year={2010},
  volume={22 6},
  pages={453-67}
}
IL-31 is a novel T(h) type 2 cytokine that can induce pruritus and dermatitis in mice resembling human atopic dermatitis (AD). Eosinophil infiltration in skin lesions is a predominant pathological feature of AD. In the present study, we investigated the effects of IL-31 on the activation of human eosinophils and epidermal keratinocytes. Eosinophils and keratinocytes were cultured either together or separately in the presence or absence of IL-31 stimulation. IL-31 could significantly induce the… CONTINUE READING
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