Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.

  title={Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.},
  author={Aaron M Cypess and Lauren S Weiner and Carla Roberts-Toler and Elisa Franquet El{\'i}a and Skyler H Kessler and Peter A. Kahn and J. R. English and Kelly Chatman and Sunia A. Trauger and Alessandro Doria and G. M. Kolodny},
  journal={Cell metabolism},
  volume={21 1},
Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT) is a potential approach to treat obesity and diabetes. The class of β3-adrenergic receptor (AR) agonists stimulates rodent BAT, but this activity has never been demonstrated in humans. Here we determined the ability of 200 mg oral mirabegron (Myrbetriq, Astellas Pharma, Inc.), a β3-AR agonist currently approved to treat overactive bladder, to stimulate BAT as compared to placebo. Mirabegron led to higher… CONTINUE READING
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