Activation of human CIC-2 Cl- channels: implications for cystic fibrosis.

@article{Cuppoletti2000ActivationOH,
  title={Activation of human CIC-2 Cl- channels: implications for cystic fibrosis.},
  author={John Cuppoletti and Kirti P. Tewari and A. M. Sherry and Danuta H. Malinowska},
  journal={Clinical and experimental pharmacology & physiology},
  year={2000},
  volume={27 11},
  pages={896-900}
}
1. The CIC-2 Cl- channels are present in the adult human lung epithelia and, therefore, are a potential target for therapy in cystic fibrosis. 2. Activators of CIC-2 Cl- channels that may have physiological relevance include activation by reduced external pH, protein kinase A and arachidonic acid. 3. Activators of CIC-2 Cl- channels that have therapeutic potential include amidation and omeprazole and, perhaps, effectors of arachidonic acid metabolism. 

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