Activation of human B lymphocytes through CD40 and interleukin 4.

  title={Activation of human B lymphocytes through CD40 and interleukin 4.},
  author={Alfredo del Valle and C E Zuber and Thierry Defrance and Odile Djossou and Menno A. de Rie and Jacques Banchereau},
  journal={European journal of immunology},
  volume={19 8},
We have produced and characterized a new CD40 monoclonal antibody, mAb 89, which in the presence of anti-IgM antibodies co-stimulates to induce B cell proliferation. mAb 89 activates resting B cells as shown by an increase in cell volume and an enhanced subsequent proliferation of B cells in response to anti-IgM antibody. However, mAb 89 does not prepare B cells to respond to the growth-promoting activity of interleukin (IL) 2 or IL 4. Unlike IL 2 and IL 4, mAb 89 only weakly stimulates the… CONTINUE READING

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