Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors.

@article{Chio1994ActivationOH,
  title={Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors.},
  author={Christopher L. Chio and Michael Lajiness and Rita M. Huff},
  journal={Molecular pharmacology},
  year={1994},
  volume={45 1},
  pages={51-60}
}
Recombinant rat D3 dopamine receptors heterologously expressed in Chinese hamster ovary (CHO) cells are functionally coupled to endogenous G proteins. The affinity of the receptors for agonists is regulated by guanine nucleotides in the same manner as that of other G protein-linked receptors. The magnitude of the change in affinity induced by GTP is much less, however, than what is observed for recombinant rat D2 receptors expressed in CHO cells at similar densities. The striking difference is… CONTINUE READING
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