Activation of heterologous gene expression by the large isoform of hepatitis delta antigen.

@article{Wei1998ActivationOH,
  title={Activation of heterologous gene expression by the large isoform of hepatitis delta antigen.},
  author={Ying Wei and Donald E Ganem},
  journal={Journal of virology},
  year={1998},
  volume={72 3},
  pages={2089-96}
}
Hepatitis delta virus (HDV) encodes two isoforms of its principal gene product, hepatitis delta antigen (HDAg). These two forms play distinctive and complementary roles in viral replication. Here we report that the large (LHDAg), but not the small (SHDAg), isoform of HDAg has the capacity to activate the expression of cotransfected genes driven by a variety of promoters, including the pre-S, S, and C promoters of hepatitis B virus. Mutational analysis of the C-terminal 19 amino acids unique to… CONTINUE READING

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